ADVANCED IMAGING AND DIFFRACTION TOOLS FOR TRANSMISSION ELECTRON MICROSCOPY
ORGANICS & PHARMACEUTICALS/PROTEINS
Polymorphism is very important in the pharmaceutical industry where it also occurs very frequently in other organic materials like pigments and proteins. Physical properties of organic compounds (specially for drug design) depend on their precise crystal structure. 3D electron diffraction tomography sheds light to the crystal structure of organic compounds and proteins.
3D ELECTRON DIFFRACTION TOMOGRAPHY – ORGANICS-PHARMACEUTICALS
Schmidt, M. U., et al. “Electron Diffraction, X-Ray Powder Diffraction and Pair-Distribution- Function Analyses to Determine the Crystal Structures of Pigment Yellow 213, C23H21N5O9.” Acta Crystallographica Section B: Structural Science, vol. 65, no. 2, 2009, pp. 189–99, doi:10.1107/S0108768109003759.
Lanza, A., et al. “Nanobeam Precession-Assisted 3D Electron Diffraction Reveals a New Polymorph of Hen Egg-White Lysozyme.” IUCrJ, vol. 6, International Union of Crystallography, 2019, pp. 178–88, doi:10.1107/S2052252518017657.