Advanced CCD and Direct Detection cameras
for high end 4D-STEM/SPED applications
Advanced cameras as well as latest generation Direct Detection cameras specifically designed for TEM can be used for ED pattern acquisition for optimized ASTAR , ADT 3D, and strain applications.Use of such advanced cameras enable to increase the speed of ED pattern collection (eg 1000 fps*)and consequently decrease acquisition time for each 4D-STEM/SPED map (speeding up the collection of data with a high-throughput and efficient setup).
Such cameras may also allow to collect ED patterns at much lower dose rates, making possible to study beam sensitive materials and collect ASTAR orientation and strain maps with very low noise while revealing fine structural details.
*The maximum frame rate, number of pixels, their related dynamic range and field-of-view are ultimately specified by the camera provider.
ED pattern acquisition for optimized ASTAR , ADT 3D and strain applications can be obtained through special TOPSPIN module for various CCD /DD cameras : Merlin QD, Dectris Quadro, Gatan Orius , Gatan OneView, Gatan Rio, Amsterdam Scientific Cheetah Medipix
Precession Electron Diffraction using a Direct Electron Detector
4D-STEM / Precession Electron Diffraction & Pixelated Detectors
Observation of dynamic 3D motion of nanoparticles combined with 4D-STEM orientation and phase map in Liquid-Cell STEM microscopy
3D Electron Diffraction / Micro-ED for Structural Characterization of beam sensitive API using Pixelated detectors
Searching for Api Polymorphs and solving their nanocrystal structures by Electro Diffraction Tomography
New Timepix Detector Enables Single Crystal Structure determination from Beams Sensitive Organic Materials using Electron Diffraction
ADT 3D TOMOGRAPHY, ASTAR , STRAIN, IN SITU & DD cameras
- E Van Genderen, et al “Ab initio structure determination of nanocrystals of organic pharmaceutical compounds by electron diffraction at room temperature using a Timepix quantum area direct electron detector“ (2016). A72, 236-242 DOI:10. 1107/S2053273315022500
- P.P. Das, et al Crystal Structures of Two Important Pharmaceuticals Solved by 3D Precession Electron Diffraction Tomography Organic Process Research & Development (2018) DOI 10.1021/acs.orpd.8b00149
- G. R. Woollam, et al “Structural analysis of metastable pharmaceutical Loratadine form II, by 3D electron diffraction and DFT+D energy minimization” CrystEngComm (2020) DOI: 10.1039/d0ce01216e
- Ian MacLaren et al “A Comparison of a Direct Electron Detector and a High-Speed Video Camera for a Scanning Precession Electron Diffraction Phase and Orientation Mapping” Microscopy and Microanalysis (2020), 1–7 DOI:10.1017/S1431927620024411
- P. P. Das et al “Crystal Structure of Linagliptin Hemihydrate Hemiethanolate (C25H28N8O2)2(H2O)(C2H5OH) from 3D Electron Diffraction Data, Rietveld Refinement, and Density Functional Theory Optimization” Crystal Growth & Design DOI:10.1021/acs.cgd.0c01379
- Y.Wang et al “Elucidatrion of the Elusive structure and Formula of the Active Pharmaceutical Ingredient Bismuth Subgallate by Continuous Rotation Electron Diffraction Chem Commun.2017, 53, 2018-21, DOI:10.1039/C7CCo3180G
- E.Broadhurst et al “Polymorph evolution during crystal growth by electron diffraction” IUCr J DOI: 10.1107/S2052252519016105
- M.Gemmi et al “A new method based on electron diffraction for detecting nanoparticles in injectable medicines” Journal of Pharmaceutical Sciences DOI: 10.1016/j.xphs.2019.07.008
